Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | PLD2 | O14939 | 1/20 | 0.32 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9225797 | 0.77 | OPRL1 (0.35) | — | |
| SCHEMBL9228555 | 0.74 | ALOX5 (0.32) | KEAP1NFE2L2 | |
| SCHEMBL9228833 | 0.73 | ALOX5 (0.34) | — | |
| SCHEMBL9043945 | 0.72 | AR (0.31) | PLD2PLD1GSK3AGSK3B | |
| SCHEMBL13847291 | 0.67 | AR (0.36) | CCNCCDK8HASPINGSK3AGSK3B | |
| SCHEMBL27947140 | 0.65 | PDK2 (0.55) | — | |
| SCHEMBL9044793 | 0.63 | GAA (0.32) | GSK3AGSK3B | |
| SCHEMBL24389994 | 0.63 | PDK2 (0.39) | CCNCCDK8HASPIN | |
| SCHEMBL9200390 | 0.63 | NPC1 (0.42) | — | |
| SCHEMBL15650500 | 0.62 | EPHX2 (0.49) | CCNCCDK8HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640087-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023405-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-25 | — | — | WO | disclosed |