Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9228833 | 0.84 | ALOX5 (0.34) | OPRM1MEN1KMT2AMAPK1LMNA | |
| SCHEMBL9231629 | 0.84 | LMNA (0.42) | AKR1C3CYP2D6TSHRPOLBMEN1 | |
| SCHEMBL9230218 | 0.77 | KEAP1 (0.34) | — | |
| SCHEMBL9230320 | 0.77 | OPRL1 (0.38) | OPRL1OPRM1CYP2D6TSHRBRD4 | |
| SCHEMBL11842992 | 0.77 | BRD4 (0.40) | AKR1C3BRD4POLBGAAALDH1A1 | |
| SCHEMBL9232012 | 0.77 | AKR1C3 (0.56) | AKR1C3BRD4POLBMEN1KMT2A | |
| SCHEMBL11849044 | 0.76 | POLB (0.47) | OPRL1OPRM1AKR1C3CYP2D6TSHR | |
| SCHEMBL9231114 | 0.75 | AKR1C3 (0.42) | OPRL1OPRM1AKR1C3POLBMEN1 | |
| SCHEMBL9232019 | 0.74 | ALDH1A1 (0.40) | OPRL1OPRM1TSHRBRD4POLB | |
| SCHEMBL9228892 | 0.74 | LRRK2 (0.41) | AKR1C3BRD4LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640087-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023405-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-25 | — | — | WO | disclosed |