Methane

Methane

SCHEMBL9230653

C.COC(=O)COC(=O)[C@@H](C)c1ccc(OC(=O)c2ccc(NC(=N)N)cc2)cc1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.41
ACR P10323 4/20 0.41
PRSS1 P07477 3/20 0.41
MEN1 O00255 6/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
F2 P00734 2/20 0.38
F7 P08709 2/20 0.38
F10 P00742 1/20 0.38
HGFAC Q04756 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
HTT P42858 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9236282 0.95 ACR (0.43) KMT2AACRPRSS1MEN1SMN1; SMN2
Methane SCHEMBL9231738 0.88 KMT2A (0.46) KMT2AMEN1SMN1; SMN2F7GAA
SCHEMBL9230197 0.87 PRSS1 (0.44) KMT2AACRPRSS1MEN1SMN1; SMN2
SCHEMBL9232936 0.87 PRSS1 (0.44) KMT2AACRPRSS1MEN1SMN1; SMN2
SCHEMBL11427664 0.87 KMT2A (0.50) KMT2AACRPRSS1MEN1SMN1; SMN2
SCHEMBL9235287 0.87 ACR (0.42) KMT2AACRPRSS1MEN1SMN1; SMN2
SCHEMBL9232990 0.86 KMT2A (0.42) KMT2AACRPRSS1MEN1SMN1; SMN2
SCHEMBL9231884 0.86 PRSS1 (0.44) KMT2AACRPRSS1MEN1SMN1; SMN2
SCHEMBL11274623 0.86 RECQL (0.49) KMT2AACRPRSS1MEN1SMN1; SMN2
SCHEMBL9231727 0.86 KMT2A (0.42) KMT2AACRPRSS1MEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0673924-A1 PROPIONIC ACID DERIVATIVE TEIKOKU CHEMICAL INDUSTRY CO., LTD. (JP) 1995-09-27 EP disclosed