Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 3/20 | 0.40 |
| ▸ | ACR | P10323 | 3/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.40 |
| ▸ | KLK1 | P06870 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | C1R | P00736 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL9230653 | 0.95 | KMT2A (0.41) | ACRPRSS1F2KMT2AMEN1 | |
| SCHEMBL9230197 | 0.92 | PRSS1 (0.44) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9232936 | 0.92 | PRSS1 (0.44) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9235287 | 0.92 | ACR (0.42) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9232990 | 0.91 | KMT2A (0.42) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9231727 | 0.91 | KMT2A (0.42) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9231884 | 0.91 | PRSS1 (0.44) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9282878 | 0.91 | ACR (0.38) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9235227 | 0.90 | ACR (0.47) | ACRPRSS1KLK1F2KMT2A | |
| SCHEMBL9231748 | 0.89 | ACR (0.40) | ACRPRSS1KLK1F2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673924-A1 | PROPIONIC ACID DERIVATIVE | TEIKOKU CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-09-27 | — | — | EP | disclosed |