Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 3/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9231005 | 1.00 | LSS (0.45) | LSSPSMB5BCHEACHEHRH1 | |
| Maleic Acid SCHEMBL9236893 | 0.96 | LSS (0.45) | LSSPSMB5BCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL9236898 | 0.96 | LSS (0.45) | LSSPSMB5BCHEACHEHRH1 | |
| Maleic Acid SCHEMBL9236952 | 0.95 | PSMB5 (0.43) | LSSPSMB5BCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL9236957 | 0.95 | PSMB5 (0.43) | LSSPSMB5BCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL9234624 | 0.94 | LSS (0.43) | LSSPSMB5BCHEACHEKDM4E | |
| Maleic Acid SCHEMBL9235575 | 0.94 | MAPK14 (0.40) | LSSPSMB5BCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL9235580 | 0.94 | MAPK14 (0.40) | LSSPSMB5BCHEACHEHRH1 | |
| Fumaric Acid SCHEMBL9234618 | 0.94 | LSS (0.43) | LSSPSMB5BCHEACHEKDM4E | |
| Fumaric Acid SCHEMBL9237516 | 0.94 | BCHE (0.44) | LSSPSMB5BCHEACHEHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641564-A1 | OPTICALLY ACTIVE CONDENSED PYRAZOLE COMPOUND FOR USE IN TREATING THROMBOCYTOPENIA AND ERYTHROPENIA | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |