Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11843453 | 0.94 | AKR1C3 (0.50) | AKR1C3PGRLRRK2MAPTAKR1B1 | |
| SCHEMBL11843263 | 0.93 | AKR1C3 (0.51) | AKR1C3PGRLRRK2MAPTAKR1B1 | |
| SCHEMBL11845930 | 0.91 | AKR1C3 (0.50) | AKR1C3PGRLRRK2MAPTAKR1B1 | |
| SCHEMBL9225503 | 0.85 | AKR1C3 (0.47) | AKR1C3PGRMAPTMEN1KMT2A | |
| SCHEMBL11842992 | 0.85 | BRD4 (0.40) | AKR1C3LRRK2AKR1B1BRD4MGAM | |
| SCHEMBL9231629 | 0.84 | LMNA (0.42) | AKR1C3LRRK2AKR1B1MEN1KMT2A | |
| SCHEMBL11836827 | 0.83 | AKR1C3 (0.44) | AKR1C3PGRMAPTAKR1B1MEN1 | |
| SCHEMBL11869473 | 0.82 | AKR1C3 (0.51) | AKR1C3LRRK2AKR1B1MEN1KMT2A | |
| SCHEMBL9202872 | 0.82 | AKR1C3 (0.44) | AKR1C3MAPTAKR1B1MEN1KMT2A | |
| SCHEMBL9228892 | 0.81 | LRRK2 (0.41) | AKR1C3PGRLRRK2AKR1B1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640087-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023405-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-25 | — | — | WO | disclosed |
| US-3980645-A | Fused quinazolinones and a process for production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-09-14 | — | — | US | disclosed |