Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9231629 | 0.86 | LMNA (0.42) | AKR1C3HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL9232012 | 0.85 | AKR1C3 (0.56) | AKR1C3HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL9230546 | 0.85 | LMNA (0.43) | AKR1C3HSD11B1MEN1KMT2APOLB | |
| SCHEMBL9230707 | 0.83 | AKR1C3 (0.38) | AKR1C3HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL9203731 | 0.82 | HTT (0.47) | AKR1C3PGRMEN1KMT2APOLB | |
| SCHEMBL9226322 | 0.81 | AKR1C3 (0.38) | AKR1C3MEN1KMT2APOLBGAA | |
| SCHEMBL9231114 | 0.80 | AKR1C3 (0.42) | AKR1C3HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11843453 | 0.79 | AKR1C3 (0.50) | AKR1C3PGRMEN1KMT2AGAA | |
| SCHEMBL11849044 | 0.79 | POLB (0.47) | AKR1C3HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL11843263 | 0.78 | AKR1C3 (0.51) | AKR1C3HTR7HTR1AHTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640087-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023405-A1 | USE OF TRICYCLIC PYRIMIDINE DERIVATIVES AS ANTI-VIRAL MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-25 | — | — | WO | disclosed |