Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TOP2A | P11388 | 3/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501881 | 1.00 | KDM4E (0.36) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL6660578 | 1.00 | KDM4E (0.36) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL6217185 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10364559 | 0.84 | ALDH1A1 (0.52) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL500694 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL9096418 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL6662420 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL9236365 | 0.83 | TOP2A (0.38) | KDM4EALDH1A1TOP2ATOP2BCYP1A2 | |
| SCHEMBL9047223 | 0.83 | TOP2A (0.38) | KDM4EALDH1A1TOP2ATOP2BCYP1A2 | |
| SCHEMBL7607385 | 0.83 | TOP2A (0.38) | KDM4EALDH1A1TOP2ATOP2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653425-A1 | 1-(2-Fluorocyclopropyl)-quinolone- and naphthyridone carboxylic acid derivatives, their preparation and their use as antibacterials | BAYER AG (DE) | 1995-05-17 | — | — | EP | disclosed |