Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.76 |
| ▸ | CYTH3 | O43739 | 2/20 | 0.76 |
| ▸ | AKT1 | P31749 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9289577 | 0.86 | PDPK1 (1.00) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL10064402 | 0.81 | EPHX1 (0.63) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL28433444 | 0.80 | RAB9A (0.72) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL14096601 | 0.80 | ALDH1A1 (0.71) | MAPTRAB9AALDH1A1HPGDEPHX1 | |
| SCHEMBL9284002 | 0.79 | EPHX1 (0.60) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL13196961 | 0.79 | MAPT (1.00) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL5212053 | 0.79 | MAPT (0.74) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL28435408 | 0.78 | EPHX1 (0.83) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL9286984 | 0.78 | PDPK1 (0.73) | PDPK1CYTH3AKT1MAPTRAB9A | |
| SCHEMBL8612483 | 0.77 | EPHX1 (0.77) | MAPTRAB9AALDH1A1HPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040585-B2 | Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof | TUFTS UNIVERSITY (US) | 2015-05-26 | — | — | US | disclosed |
| US-20140187639-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-07-03 | — | — | US | disclosed |
| US-8628961-B2 | Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof | TUFTS UNIVERSITY (US) | 2014-01-14 | — | — | US | disclosed |
| US-20120136033-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120016033-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016033-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | PIP5K1A, PIP5K1B, PIP4K2A | PDPK1 61/4885CYTH3 109/4885AKT1 68/4885 |
| US-20120136033-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | PIP5K1A, PIP5K1B, PIP5K1C | PDPK1 61/4885CYTH3 142/4885AKT1 95/4885 |
| US-20140187639-A1 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof | PIP5K1A, PIP5K1B, PIP4K2A | PDPK1 61/4885CYTH3 109/4885AKT1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.