Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250932 | 0.79 | PNMT (0.33) | PNMTKEAP1 | |
| SCHEMBL13545452 | 0.71 | PNMT (0.38) | PNMTHTR1ADRD2HTR2A | |
| SCHEMBL710185 | 0.65 | KEAP1 (0.50) | PNMTKEAP1HTR1ADRD2HTR2A | |
| SCHEMBL5851674 | 0.62 | MAP2K1 (0.41) | KEAP1 | |
| SCHEMBL21906175 | 0.62 | KEAP1 (0.42) | KEAP1 | |
| SCHEMBL4303248 | 0.61 | PARP10 (0.47) | PNMT | |
| SCHEMBL22726002 | 0.60 | AOC3 (0.47) | KEAP1DRD2AOC3 | |
| SCHEMBL21266522 | 0.60 | CA1 (0.49) | KEAP1AOC3 | |
| SCHEMBL22618988 | 0.60 | KEAP1 (0.41) | KEAP1 | |
| SCHEMBL13488121 | 0.60 | CA1 (0.45) | KEAP1HTR1ADRD2HTR2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585377-A | CONTROLLING INTRAOCULAR PRESSURE | ALCON LABORATORIES, INC. (US) | 1996-12-17 | — | — | US | disclosed |
| US-5378703-A | FOR CONTROLLING INTRAOCULAR PRESSURE | ALCON LABORATORIES, INC. (US) | 1995-01-03 | — | — | US | disclosed |