Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9396470 | 0.78 | CHEK1 (0.41) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL2093822 | 0.76 | TSHR (0.39) | CYP3A4SMN1; SMN2ALDH1A1TSHRGAA | |
| SCHEMBL16838887 | 0.75 | CHEK1 (0.45) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL2092838 | 0.74 | ACHE (0.36) | SMN1; SMN2TDP1ALDH1A1TSHRGAA | |
| SCHEMBL2089946 | 0.74 | TSHR (0.38) | SMN1; SMN2ALDH1A1TSHRGAAMAPT | |
| SCHEMBL2090250 | 0.74 | C1R (0.37) | SMN1; SMN2ALDH1A1TSHRGAAMAPT | |
| SCHEMBL10532261 | 0.74 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1TSHRGAAMAPT | |
| SCHEMBL15268120 | 0.74 | CHEK1 (0.48) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL113870 | 0.74 | CHEK1 (0.60) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29707613 | 0.74 | CHEK1 (0.60) | CHEK1NEK2LIMK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | claimed |