Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | F2R | P25116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9237284 | 0.87 | POLB (0.53) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| Bicarbonate SCHEMBL9239335 | 0.86 | POLB (0.52) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL9236118 | 0.85 | ITGB3 (0.45) | HTTPOLBTSHRITGB3ITGA2B | |
| Bicarbonate SCHEMBL15226037 | 0.84 | HTT (0.68) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| Bicarbonate SCHEMBL9235058 | 0.83 | HTT (0.49) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| Bicarbonate SCHEMBL9239312 | 0.83 | HTT (0.49) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| Bicarbonate SCHEMBL9233396 | 0.82 | HTT (0.48) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL652054 | 0.80 | HTT (0.72) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL14393744 | 0.80 | HTT (0.62) | HTTKDM4EALDH1A1POLBHSD17B10 | |
| Bicarbonate SCHEMBL9235732 | 0.80 | MAPK1 (0.65) | HTTKDM4EALDH1A1POLBEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |