Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.43 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9239335 | 0.99 | POLB (0.52) | POLBPKMTSHRKDM4EALDH1A1 | |
| Bicarbonate SCHEMBL9236121 | 0.87 | HTT (0.55) | POLBPKMTSHRKDM4EALDH1A1 | |
| SCHEMBL9237279 | 0.86 | DRD2 (0.43) | POLBPKMTSHRKDM4EALDH1A1 | |
| Bicarbonate SCHEMBL9235048 | 0.82 | DRD2 (0.55) | POLBALDH1A1CHRM3SIGMAR1CHRM5 | |
| Bicarbonate SCHEMBL9238422 | 0.80 | DRD2 (0.57) | POLBPKMTSHRALDH1A1DRD2 | |
| Bicarbonate SCHEMBL15226037 | 0.79 | HTT (0.68) | POLBPKMTSHRKDM4EALDH1A1 | |
| SCHEMBL22291286 | 0.78 | ITGB3 (0.46) | CHRM3DRD2DRD3TPSAB1TPSD1 | |
| Bicarbonate SCHEMBL9235058 | 0.77 | HTT (0.49) | POLBPKMTSHRKDM4EALDH1A1 | |
| SCHEMBL652054 | 0.76 | HTT (0.72) | POLBPKMTSHRKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL27392976 | 0.75 | HTT (0.70) | POLBPKMTSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |