Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.76 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.76 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | DRD4 | P21917 | 3/20 | 0.69 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61848 | 0.90 | TMEM97 (0.83) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL694949 | 0.90 | SIGMAR1 (0.82) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| Hydrochloric Acid SCHEMBL9785680 | 0.88 | SIGMAR1 (0.97) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL61320 | 0.87 | TMEM97 (0.68) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL7218186 | 0.87 | DRD4 (0.86) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL2233466 | 0.87 | KCNH2 (0.80) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL7224869 | 0.86 | SIGMAR1 (0.77) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL8274001 | 0.86 | MEN1 (0.78) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL2233461 | 0.86 | TMEM97 (0.77) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 | |
| SCHEMBL1425074 | 0.86 | SIGMAR1 (1.00) | TMEM97SIGMAR1SLC6A12MCHR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |