Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.86 |
| ▸ | DRD2 | P14416 | 8/20 | 0.86 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.79 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.79 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707354 | 0.92 | DRD2 (1.00) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL8706290 | 0.92 | DRD2 (1.00) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL61848 | 0.92 | TMEM97 (0.83) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL694949 | 0.92 | SIGMAR1 (0.82) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL14082514 | 0.90 | DRD4 (0.71) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL2233466 | 0.90 | KCNH2 (0.80) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL8706202 | 0.89 | DRD4 (0.87) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL7224869 | 0.88 | SIGMAR1 (0.77) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL8274001 | 0.88 | MEN1 (0.78) | DRD4DRD2TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL2233461 | 0.88 | TMEM97 (0.77) | DRD4DRD2TMEM97SIGMAR1SLC6A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998037064-A1 | BENZAMIDES HAVING DOPAMINE D4 RECEPTOR AFFINITY | HOECHST MARION ROUSSEL, INC. (US) | 1998-08-27 | — | — | WO | claimed |
| EP-1322612-A1 | SUBSTITUTED AMINO-AZA-CYCLOALKANES USEFUL AGAINST MALARIA | Actelion Pharmaceuticals Ltd. (CH) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024649-A1 | SUBSTITUTED AMINO-AZA-CYCLOALKANES USEFUL AGAINST MALARIA | ACTELION PHARMACEUTICALS LTD (CH) | 2002-03-28 | — | — | WO | disclosed |
| WO-1998037064-A1 | BENZAMIDES HAVING DOPAMINE D4 RECEPTOR AFFINITY | HOECHST MARION ROUSSEL, INC. (US) | 1998-08-27 | — | — | WO | disclosed |