⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460791 | 0.68 | ITGB3 (0.30) | — | |
| SCHEMBL1032285 | 0.65 | TDO2 (0.40) | — | |
| Water SCHEMBL10621554 | 0.64 | GAA (0.31) | — | |
| SCHEMBL19032024 | 0.63 | — | — | |
| SCHEMBL4276731 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL10660266 | 0.63 | GAA (0.30) | — | |
| SCHEMBL56056 | 0.63 | — | — | |
| SCHEMBL12993233 | 0.62 | — | — | |
| SCHEMBL10555075 | 0.62 | — | — | |
| SCHEMBL3801333 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49361-E1 | Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2023-01-10 | — | — | US | claimed |
| US-11339193-B2 | CDP protein secretion inhibitors | KEZAR LIFE SCIENCES (US) | 2022-05-24 | — | — | US | claimed |
| US-20220048910-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2022-02-17 | — | — | US | claimed |
| EP-3946345-A1 | METHODS OF TREATING NEUROPATHIC PAIN | Intra-Cellular Therapies, Inc. (US) | 2022-02-09 | — | — | EP | claimed |
| CN-113905737-A | Method of treating neuropathic pain | 细胞内治疗公司 | 2022-01-07 | — | — | CN | claimed |
| EP-3914235-A2 | METHODS OF TREATING ADDICTION | Intra-Cellular Therapies, Inc. (US) | 2021-12-01 | — | — | EP | claimed |
| EP-3897621-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2021-10-27 | — | — | EP | claimed |
| CN-113329742-A | Method for treating addiction | 细胞内治疗公司 | 2021-08-31 | — | — | CN | claimed |
| CN-112513065-A | CDP protein secretion inhibitors | 科智生命科学公司 | 2021-03-16 | — | — | CN | claimed |
| EP-3774850-A1 | CDP PROTEIN SECRETION INHIBITORS | Kezar Life Sciences (US) | 2021-02-17 | — | — | EP | claimed |
| EP-3191477-A1 | FUSED BICYCLIC (HETERO)AROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF CANCERS | Redx Pharma Plc (GB) | 2017-07-19 | — | — | EP | claimed |
| WO-2016038389-A1 | FUSED BICYCLIC (HETERO)AROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF CANCERS | REDX PHARMA PLC (GB) | 2016-03-17 | — | — | WO | claimed |
| US-8071772-B2 | Spirolactam bicyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-12-06 | — | — | US | claimed |
| US-8071771-B2 | Bicyclic spirohydantoin CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-12-06 | — | — | US | claimed |
| US-20090325991-A1 | Spirolactam Bicyclic CGRP Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-12-31 | — | — | US | claimed |
| US-20090176757-A1 | Bicyclic Spirohydantoin CGRP Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-07-09 | — | — | US | claimed |
| EP-1954268-A2 | SPIROLACTAM BICYCLIC CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-08-13 | — | — | EP | claimed |
| EP-1951228-A2 | BICYCLIC SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007061695-A2 | BICYCLIC SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | claimed |
| WO-2007061696-A2 | SPIROLACTAM BICYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | claimed |