Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445838 | 0.90 | LTA4H (0.62) | LTA4HEPHX2SMN1; SMN2ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL8492706 | 0.88 | LTA4H (0.60) | LTA4HEPHX2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL41690 | 0.84 | MAOA (0.72) | HRH4HRH3SMN1; SMN2MAOACHRM2 | |
| SCHEMBL25047627 | 0.83 | MEN1 (0.62) | LTA4HEPHX2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL8493877 | 0.83 | BCHE (0.72) | LTA4HEPHX2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL9081182 | 0.83 | DRD4 (0.72) | LTA4HEPHX2KDM4EBCHEGAA | |
| SCHEMBL3025568 | 0.83 | LTA4H (0.62) | LTA4HEPHX2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3963927 | 0.83 | BCHE (0.76) | BCHEKMT2A | |
| SCHEMBL13973066 | 0.82 | KDM4E (0.59) | LTA4HEPHX2SMN1; SMN2ALDH1A1HTT | |
| Bromide SCHEMBL2577914 | 0.82 | MAOA (0.69) | HRH4HRH3SMN1; SMN2MAOACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |
| US-3946119-A | Optionally substituted α-tertiary butyl-p-phenoxybenzylamines and their use as hypolipidemic agents | SANDOZ, INC. (US) | 1976-03-23 | — | — | US | disclosed |
| US-3946119-A | Optionally substituted α-tertiary butyl-p-phenoxybenzylamines and their use as hypolipidemic agents | SANDOZ, INC. (US) | 1976-03-23 | — | — | US | disclosed |