Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9234182 | 0.91 | SIGMAR1 (0.46) | LMNASIGMAR1MEN1KMT2APOLB | |
| SCHEMBL15652904 | 0.83 | HRH3 (0.50) | LMNAPOLBHRH3CARM1PRMT6 | |
| SCHEMBL19852051 | 0.83 | CARM1 (0.64) | LMNASIGMAR1MEN1KMT2APOLB | |
| SCHEMBL9234885 | 0.82 | HRH3 (0.47) | SIGMAR1HRH3L3MBTL1 | |
| SCHEMBL9236311 | 0.81 | HRH3 (0.49) | SIGMAR1HRH3L3MBTL1ALDH1A1 | |
| SCHEMBL9471541 | 0.81 | LTA4H (0.63) | SIGMAR1HRH3CARM1PRMT6 | |
| SCHEMBL9234222 | 0.80 | KCNJ1 (0.67) | SIGMAR1HRH3MAOA | |
| SCHEMBL4238055 | 0.80 | HRH3 (0.58) | SIGMAR1HRH3CARM1PRMT6MAOA | |
| SCHEMBL2761933 | 0.79 | SPHK1 (0.63) | SIGMAR1HRH3 | |
| SCHEMBL12803875 | 0.79 | HRH3 (0.69) | MEN1KMT2AHRH3CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649838-A1 | N-phenylalkyl/phenoxyalkyl-azetidine/pyrrozidinel piperidine/hexahydroazepine derivatives as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-04-26 | — | — | EP | disclosed |