Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910119 | 0.92 | CYP1A2 (0.40) | MMP8PIN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3179603 | 0.83 | CNR2 (0.46) | MMP8PIN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11367656 | 0.82 | PIN1 (0.37) | MMP8PIN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10806885 | 0.82 | LCK (0.43) | CYP1A2MAPTKMT2AHPGDPPARA | |
| SCHEMBL11082470 | 0.81 | PIN1 (0.38) | MMP8PIN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11367652 | 0.80 | CYP1A2 (0.39) | MMP8PIN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2912931 | 0.79 | PIN1 (0.51) | MMP8PIN1CYP1A2CYP2C19POLB | |
| SCHEMBL14747879 | 0.79 | PIN1 (0.51) | MMP8PIN1CYP1A2CYP2C19POLB | |
| SCHEMBL25308703 | 0.78 | TSHR (0.42) | CYP1A2CYP2C9CYP2C19POLBALDH1A1 | |
| SCHEMBL9831106 | 0.77 | TSHR (0.39) | PIN1CYP1A2CYP2C9CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5418250-A | Hypotensive | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-23 | — | — | US | disclosed |
| US-5185351-A | Hypotensive agents; for treatment of congestive heart failure, renal failure and glaucoma | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-09 | — | — | US | disclosed |