Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9238362 | 1.00 | DHODH (0.59) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL8614000 | 0.82 | DHODH (0.68) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL8615187 | 0.82 | DHODH (0.68) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL9157076 | 0.81 | DHODH (0.64) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL9233110 | 0.80 | DHODH (0.56) | DHODHMEN1KMT2AG6PDCACNA1B | |
| SCHEMBL15196662 | 0.80 | DHODH (0.62) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL8620911 | 0.79 | DHODH (0.64) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL9129374 | 0.79 | DHODH (0.64) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL18118641 | 0.78 | DHODH (0.70) | DHODHMAPTNPC1RAB9AMEN1 | |
| SCHEMBL16741993 | 0.78 | DHODH (0.70) | DHODHMAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652214-A1 | N-Aryl-2-cyano-3-hydroxy propenamide derivatives, a method for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-05-10 | — | — | EP | disclosed |