Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.57 |
| ▸ | GABRD | O14764 | 3/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.57 |
| ▸ | GABRE | P78334 | 3/20 | 0.57 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.57 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.57 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.57 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3955123 | 0.92 | MEN1 (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6650965 | 0.88 | MGAM (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2340821 | 0.81 | MAPT (0.81) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL22249800 | 0.81 | EGFR (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9189119 | 0.80 | KDM1A (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9238146 | 0.79 | GABRP (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2282515 | 0.79 | AHR (0.78) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL13855909 | 0.76 | GABRP (0.75) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17396637 | 0.76 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL6526017 | 0.76 | MEN1 (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652214-A1 | N-Aryl-2-cyano-3-hydroxy propenamide derivatives, a method for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-05-10 | — | — | EP | disclosed |