Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.47 |
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9240334 | 1.00 | ACE (0.47) | ACEMMEMTNR1AMTNR1BMAOA | |
| SCHEMBL7398528 | 0.84 | MME (0.37) | ACEMMEMTNR1AMTNR1B | |
| SCHEMBL7398531 | 0.84 | MME (0.37) | ACEMMEMTNR1AMTNR1B | |
| SCHEMBL7394099 | 0.84 | MTNR1A (0.44) | ACEMTNR1AMTNR1BMAOAMAOB | |
| SCHEMBL7394102 | 0.84 | MTNR1A (0.44) | ACEMTNR1AMTNR1BMAOAMAOB | |
| SCHEMBL7488830 | 0.82 | MME (0.42) | ACEMMEPPARGPPARA | |
| SCHEMBL7488825 | 0.82 | MME (0.42) | ACEMMEPPARGPPARA | |
| SCHEMBL7400828 | 0.82 | MME (0.49) | ACEMMEPPARGPPARA | |
| SCHEMBL7400830 | 0.82 | MME (0.49) | ACEMMEPPARGPPARA | |
| SCHEMBL7399675 | 0.82 | MME (0.40) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |