Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 5/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394099 | 1.00 | MTNR1A (0.44) | MTNR1AMTNR1BMAOAMAOBACE | |
| Amantadine SCHEMBL7394660 | 0.86 | MTNR1A (0.34) | MTNR1AMTNR1BMAOAMAOBACE | |
| Amantadine SCHEMBL7398747 | 0.86 | MTNR1A (0.34) | MTNR1AMTNR1BMAOAMAOBACE | |
| Amantadine SCHEMBL7394662 | 0.86 | MTNR1A (0.34) | MTNR1AMTNR1BMAOAMAOBACE | |
| SCHEMBL9240331 | 0.84 | ACE (0.47) | MTNR1AMTNR1BMAOAMAOBACE | |
| SCHEMBL9240334 | 0.84 | ACE (0.47) | MTNR1AMTNR1BMAOAMAOBACE | |
| SCHEMBL9240332 | 0.83 | MME (0.39) | ACEALDH1A1 | |
| SCHEMBL7393328 | 0.83 | MME (0.39) | ACEALDH1A1 | |
| SCHEMBL7398652 | 0.82 | MMP1 (0.40) | ACEALDH1A1 | |
| SCHEMBL7398653 | 0.82 | MMP1 (0.40) | ACEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | claimed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | claimed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | claimed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | claimed |