Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PNP | P00491 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303816 | 0.86 | KDM4E (0.51) | KDM4ENPC1PNPPDE4APDE4B | |
| SCHEMBL17186441 | 0.86 | ADORA3 (0.48) | KDM4ENPC1PNPOPRK1PDE4A | |
| Hydrochloric Acid SCHEMBL17186519 | 0.85 | ADORA3 (0.47) | KDM4ENPC1PNPOPRK1PDE4A | |
| Hydrochloric Acid SCHEMBL18605970 | 0.85 | KDM4E (0.50) | KDM4ENPC1PNPPDE4APDE4B | |
| Hydrochloric Acid SCHEMBL17186506 | 0.85 | PNP (0.53) | KDM4ENPC1PNPOPRK1PDE4A | |
| SCHEMBL3308563 | 0.85 | PNP (0.51) | NPC1PNPPDE4APDE4BPDE4C | |
| SCHEMBL1262627 | 0.85 | PNP (0.51) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1533551 | 0.84 | MPO (0.54) | PNPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3021043 | 0.84 | PNP (0.50) | KDM4EPNPPDE4APDE4BPDE4C | |
| SCHEMBL3310277 | 0.84 | PNP (0.50) | PNPPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7278146-A | — | — | None | — | — | JP | disclosed |
| CN-100379750-C | Inhibitors of nucleoside phosphorylases and nucleosidases | EINSTEIN COLL MED (US) | 2008-04-09 | — | — | CN | disclosed |
| CN-1692120-A | Nucleoside phosphorylase and nucleosidase inhibitors | EINSTEIN COLL MED (US) | 2005-11-02 | — | — | CN | disclosed |
| JP-H07278146-A | BENZYLGUANINE DERIVATIVE | TOAGOSEI CO LTD | 1995-10-24 | — | — | JP | disclosed |