Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964106 | 0.79 | PBRM1 (0.41) | ACHEPBRM1ALDH1A1MAPTHPGD | |
| SCHEMBL14430381 | 0.79 | PBRM1 (0.41) | ACHEPBRM1ALDH1A1MAPTHPGD | |
| SCHEMBL11917771 | 0.79 | PBRM1 (0.41) | ACHEPBRM1ALDH1A1MAPTHPGD | |
| SCHEMBL2298063 | 0.79 | PBRM1 (0.41) | ACHEPBRM1ALDH1A1MAPTHPGD | |
| SCHEMBL11927529 | 0.79 | TYMS (0.42) | ACHEPBRM1ALDH1A1MAPTHPGD | |
| Bromide SCHEMBL2296695 | 0.78 | PBRM1 (0.40) | ACHEPBRM1ALDH1A1MAPTHPGD | |
| SCHEMBL13568681 | 0.76 | TXNRD1 (0.50) | PBRM1ALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL15800519 | 0.75 | KDM4E (0.53) | ALDH1A1MAPTHPGDKDM4EMEN1 | |
| SCHEMBL668042 | 0.74 | MAPT (0.55) | PBRM1ALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL4686035 | 0.74 | GPR35 (0.41) | PBRM1ALDH1A1MAPTHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457237-A | Dihydroxyindanone tyrosine kinase inhibitors | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0586479-A1 | DIHYDROXYINDANONE TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021641-A1 | DIHYDROXYINDANONE TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1992-12-10 | — | — | WO | disclosed |