Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.69 |
| ▸ | MGLL | Q99685 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TACR2 | P21452 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255076 | 0.89 | HSD11B1 (0.54) | HSD11B1MGLLMEN1KMT2AMAPT | |
| SCHEMBL9252527 | 0.87 | HSD11B1 (0.53) | HSD11B1MGLLMEN1KMT2AMAPT | |
| SCHEMBL9254041 | 0.87 | HSD11B1 (0.53) | HSD11B1MGLLMEN1KMT2AMAPT | |
| SCHEMBL1239981 | 0.87 | HSD11B1 (0.68) | HSD11B1MGLLKDM4EMAPTATM | |
| SCHEMBL9257637 | 0.85 | HSD11B1 (0.51) | HSD11B1MGLLMEN1KMT2AMAPT | |
| SCHEMBL9379111 | 0.81 | HSD11B1 (0.54) | HSD11B1MGLLKDM4EMEN1KMT2A | |
| SCHEMBL29448588 | 0.79 | KMT2A (0.77) | HSD11B1MGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL6212608 | 0.78 | HSD11B1 (0.74) | HSD11B1MGLLKDM4EALDH1A1POLB | |
| SCHEMBL14640729 | 0.78 | MEN1 (0.56) | HSD11B1MGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL4192633 | 0.78 | HSD11B1 (0.65) | HSD11B1MGLLMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441967-A | Treating cerebral edema; anticholinesterase or brain function-improving agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| CN-1024548-C | Cyclic amine compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-05-18 | — | — | CN | disclosed |
| US-5294625-A | 1-benzyl,4-((4-dialkylaminophenyl)carbonyl)piperidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0378207-B1 | CYCLIC AMINE COMPOUNDS AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-5177087-A | Cerebral edema, cholinesterase inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| CN-1053231-A | Cyclic amine compound and uses thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1991-07-24 | — | — | CN | disclosed |
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |