Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 9/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | PROC | P04070 | 1/20 | 0.44 |
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249572 | 0.94 | ITGB3 (0.56) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL9252708 | 0.92 | CHEK2 (0.51) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL8863519 | 0.90 | HDAC1 (0.52) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL9255053 | 0.89 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL9251361 | 0.89 | HDAC6 (0.55) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL9255433 | 0.89 | JAK2 (0.50) | HDAC1HDAC8HDAC6ITGB3ITGA2B | |
| SCHEMBL9251884 | 0.88 | HDAC1 (0.50) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL9247609 | 0.88 | HDAC6 (0.56) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL9255982 | 0.87 | JAK2 (0.52) | ITGB3ITGA2BF2PTGER4JAK2 | |
| SCHEMBL9249002 | 0.87 | ITGB3 (0.50) | HDAC1HDAC8HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | claimed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | claimed |
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |