Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 1/20 | 0.85 |
| ▸ | JUN | P05412 | 1/20 | 0.66 |
| ▸ | KRAS | P01116 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.60 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.59 |
| ▸ | TUBB | P07437 | 2/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249797 | 1.00 | DBH (0.85) | DBHJUNKRASLMNAMAPT | |
| SCHEMBL7288785 | 0.92 | DBH (1.00) | DBHJUNKRASLMNAMAPT | |
| SCHEMBL7288782 | 0.92 | DBH (1.00) | DBHJUNKRASLMNAMAPT | |
| SCHEMBL6349920 | 0.84 | KRAS (0.74) | DBHKRASLMNAMAPTHTT | |
| SCHEMBL6129099 | 0.84 | KRAS (0.74) | DBHKRASLMNAMAPTHTT | |
| SCHEMBL3198145 | 0.83 | JUN (0.81) | DBHJUNLMNAMAPTHTT | |
| SCHEMBL3198139 | 0.83 | JUN (0.81) | DBHJUNLMNAMAPTHTT | |
| SCHEMBL14820484 | 0.83 | ABCG2 (0.84) | KRASALDH1A1TNFRSF1AABCG2TUBB1 | |
| SCHEMBL14800858 | 0.83 | ABCG2 (0.84) | KRASALDH1A1TNFRSF1AABCG2TUBB1 | |
| SCHEMBL17504463 | 0.82 | JUN (0.75) | DBHJUNLMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446194-A | Pharmacologically active catechol derivatives | ORION-YHTYMA OY (FI) | 1995-08-29 | — | — | US | disclosed |
| US-5283352-A | Transferase inhibitor | ORION-YHTYMA OY (FI) | 1994-02-01 | — | — | US | disclosed |
| US-5112861-A | Inhibitors of catechol-methyl-transferase enzyme, levodopa | ORION-YHTYMA OY (FI) | 1992-05-12 | — | — | US | disclosed |
| US-4963590-A | ENZYME INHIBITOR FOR TREATING PARKINSON'S DISEASE ALONG WITH DOPA;POTENTIATION | ORION-YHTYMA OY (FI) | 1990-10-16 | — | — | US | disclosed |