Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251200 | 1.00 | L3MBTL1 (0.37) | L3MBTL1TSHRTDP1ALDH1A1HSD17B10 | |
| SCHEMBL16766773 | 0.87 | PPARG (0.42) | L3MBTL1TSHRTDP1ALDH1A1MAPK1 | |
| SCHEMBL9334631 | 0.85 | TSHR (0.36) | L3MBTL1TSHRTDP1ALDH1A1HSD17B10 | |
| SCHEMBL7370924 | 0.83 | PPARG (0.42) | L3MBTL1TSHRTDP1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL9257473 | 0.79 | TSHR (0.35) | TSHRALDH1A1MAPK1KDM4EHTR2A | |
| SCHEMBL10490158 | 0.78 | MAPT (0.45) | TSHRALDH1A1MAPK1KDM4EHTR2A | |
| SCHEMBL17918582 | 0.73 | KMT2A (0.45) | L3MBTL1TSHRTDP1HSD17B10MAPK1 | |
| SCHEMBL27492109 | 0.73 | GAA (0.54) | L3MBTL1TSHRTDP1ALDH1A1HSD17B10 | |
| SCHEMBL10698578 | 0.72 | TSHR (0.37) | TSHRALDH1A1MAPK1KDM4EHTR2A | |
| SCHEMBL700153 | 0.72 | TSHR (0.55) | L3MBTL1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401766-A | Hypotensive agents with vasodilation | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5162362-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | disclosed |
| US-5158959-A | Treatment of hypertension | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-27 | — | — | US | disclosed |