Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 6/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251963 | 0.99 | ITGB3 (0.46) | ITGB3ITGA2BNAMPTF10PRSS1 | |
| SCHEMBL9256074 | 0.91 | ITGB3 (0.54) | ITGB3ITGA2BF10EGLN1PPARG | |
| SCHEMBL9251311 | 0.90 | MEN1 (0.43) | NAMPTF10PRSS1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9254502 | 0.90 | ITGB3 (0.53) | ITGB3ITGA2BF10EGLN1PPARG | |
| SCHEMBL9255552 | 0.89 | RHEB (0.48) | ITGB3ITGA2BNAMPTEGLN1PPARG | |
| SCHEMBL9251467 | 0.85 | JAK2 (0.49) | ITGB3ITGA2BPPARGJAK2JAK1 | |
| SCHEMBL9255544 | 0.84 | F10 (0.46) | NAMPTF10PRSS1EGLN1MEN1 | |
| SCHEMBL9251359 | 0.83 | JAK2 (0.45) | ITGB3ITGA2BF10JAK2JAK1 | |
| SCHEMBL9255433 | 0.83 | JAK2 (0.50) | ITGB3ITGA2BJAK2JAK1TYK2 | |
| Bromide SCHEMBL9248810 | 0.83 | JAK2 (0.50) | ITGB3ITGA2BF10JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |