SCHEMBL9251453

SCHEMBL9251453

BrCC=Cc1cccc(-c2ccsc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.44
CYP2A6 P11509 4/20 0.43
CYP2B6 P20813 2/20 0.43
CYP2E1 P05181 1/20 0.43
KCNH2 Q12809 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
DRD2 P14416 2/20 0.36
DRD3 P35462 2/20 0.36
ERN1 O75460 1/20 0.36
PTPRC P08575 1/20 0.36
PELI1 Q96FA3 1/20 0.35
CNR1 P21554 1/20 0.35
DRD4 P21917 1/20 0.35
ALOX5 P09917 1/20 0.34
PDGFRB P09619 2/20 0.33
PDGFRA P16234 2/20 0.33
KAT6A Q92794 1/20 0.33
GLO1 Q04760 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9251449 1.00 PRMT6 (0.44) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL9259057 0.84 PRMT6 (0.44) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL9259049 0.84 PRMT6 (0.44) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL27343281 0.84 PRMT6 (0.44) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL27343282 0.84 PRMT6 (0.44) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL10997866 0.80 PLAAT3 (0.41)
SCHEMBL9176295 0.79 PRMT6 (0.40) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL9175406 0.79 PRMT6 (0.40) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL9254817 0.79 PRMT6 (0.40) PRMT6CYP2A6CYP2B6CYP2E1KCNH2
SCHEMBL9175394 0.79 PRMT6 (0.40) PRMT6CYP2A6CYP2B6CYP2E1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5439932-A Anticholesterol agents BANYU PHARMACEUTICAL CO., LTD. (JP) 1995-08-08 US disclosed
US-5306728-A Substituted amine derivatives having antihyperlipemia activity BANYU PHARMACEUTICAL CO., LTD. (JP) 1994-04-26 US disclosed
EP-0448078-A2 Substituted amine derivatives having anti-hyperlipemia activity BANYU PHARMACEUTICAL CO., LTD. (JP) 1991-09-25 EP disclosed