Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | JAK1 | P23458 | 4/20 | 0.51 |
| ▸ | TYK2 | P29597 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9248810 | 0.99 | JAK2 (0.50) | JAK2JAK1TYK2JAK3ITGB3 | |
| SCHEMBL9253344 | 0.97 | JAK2 (0.52) | JAK2JAK1TYK2JAK3ITGB3 | |
| SCHEMBL9245485 | 0.92 | PTGER4 (0.48) | JAK2JAK1TYK2JAK3F10 | |
| SCHEMBL9255982 | 0.90 | JAK2 (0.52) | JAK2JAK1TYK2JAK3ITGB3 | |
| SCHEMBL9248606 | 0.89 | EHMT2 (0.49) | JAK2JAK1TYK2JAK3F10 | |
| SCHEMBL9247518 | 0.89 | JAK2 (0.56) | JAK2JAK1TYK2JAK3ITGB3 | |
| SCHEMBL9257115 | 0.89 | JAK2 (0.60) | JAK2JAK1TYK2JAK3ITGB3 | |
| SCHEMBL9256074 | 0.89 | ITGB3 (0.54) | JAK2JAK1TYK2JAK3ITGB3 | |
| Hydrochloric Acid SCHEMBL9254196 | 0.88 | JAK2 (0.45) | JAK2JAK1TYK2JAK3F10 | |
| SCHEMBL9252687 | 0.88 | JAK2 (0.45) | JAK2JAK1TYK2JAK3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | claimed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | claimed |