SCHEMBL9252009

SCHEMBL9252009

Nc1ccccc1C(=O)c1ccc(Oc2ccccc2Oc2ccc(C(=O)c3ccccc3N)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.62
GAA P10253 1/20 0.62
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
CA9 Q16790 1/20 0.51
CTNNB1 P35222 1/20 0.49
STS P08842 2/20 0.48
PARP10 Q53GL7 2/20 0.47
SRD5A2 P31213 1/20 0.46
PYGL P06737 1/20 0.45
KMT2A Q03164 1/20 0.44
ALDH1A1 P00352 1/20 0.43
CFTR P13569 1/20 0.43
HSD17B10 Q99714 1/20 0.43
POLB P06746 2/20 0.43
IKBKB O14920 1/20 0.43
BRAF P15056 1/20 0.43
KDM4E B2RXH2 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9243826 0.97 GAA (0.64) MAPTGAACA1CA2CA9
SCHEMBL9252016 0.91 MAPT (0.69) MAPTGAACA1CA2CA9
SCHEMBL9244900 0.91 MAPT (0.69) MAPTGAACA1CA2CA9
SCHEMBL9248330 0.88 GAA (0.70) MAPTGAACA1CA2CA9
SCHEMBL30926160 0.84 SRD5A2 (0.55) GAACTNNB1STSPARP10SRD5A2
SCHEMBL10949549 0.84 SRD5A2 (0.55) GAACTNNB1STSPARP10SRD5A2
SCHEMBL30926159 0.84 SRD5A2 (0.55) GAACTNNB1STSPARP10SRD5A2
SCHEMBL8374908 0.84 MAPT (0.87) MAPTGAACA1CA2CA9
SCHEMBL2955735 0.83 CTNNB1 (0.53) MAPTGAACTNNB1STSPARP10
SCHEMBL7758624 0.82 PARP10 (0.54) MAPTGAACTNNB1STSPARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0368006-B1 Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties DOW CHEMICAL CO (US) 1995-04-05 EP disclosed
US-5151489-A Block copolymers for compression molding to form fibers, films and laminates THE DOW CHEMICAL COMPANY (US) 1992-09-29 US disclosed
US-5098985-A Block copolymers for films, fibers, laminates or compression moldings THE DOW CHEMICAL COMPANY (US) 1992-03-24 US disclosed
EP-0392008-A4 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES 1991-09-04 EP disclosed
EP-0392008-A1 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES THE DOW CHEMICAL COMPANY (US) 1990-10-17 EP disclosed
EP-0368006-A2 Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties THE DOW CHEMICAL COMPANY (US) 1990-05-16 EP disclosed
WO-1990003995-A1 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES THE DOW CHEMICAL COMPANY (US) 1990-04-19 WO disclosed