SCHEMBL9252016

SCHEMBL9252016

Nc1ccccc1C(=O)c1ccc(Oc2ccc(Oc3ccc(C(=O)c4ccccc4N)cc3)cc2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.69
GAA P10253 1/20 0.69
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA9 Q16790 1/20 0.55
SRD5A2 P31213 4/20 0.55
PARP10 Q53GL7 3/20 0.52
POLB P06746 2/20 0.50
STS P08842 1/20 0.49
KMT2A Q03164 2/20 0.48
ALDH1A1 P00352 2/20 0.48
PARP15 Q460N3 1/20 0.48
PARP14 Q460N5 1/20 0.48
PARP16 Q8N5Y8 1/20 0.48
PARP11 Q9NR21 1/20 0.48
PARP4 Q9UKK3 1/20 0.48
CFTR P13569 1/20 0.47
HSD17B10 Q99714 1/20 0.47
BCL2 P10415 1/20 0.47
MCL1 Q07820 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9244900 1.00 MAPT (0.69) MAPTGAACA1CA2CA9
SCHEMBL9248330 0.96 GAA (0.70) MAPTGAACA1CA2CA9
SCHEMBL9252009 0.91 MAPT (0.62) MAPTGAACA1CA2CA9
SCHEMBL9243826 0.89 GAA (0.64) MAPTGAACA1CA2CA9
SCHEMBL8374908 0.88 MAPT (0.87) MAPTGAACA1CA2CA9
SCHEMBL5685223 0.86 KMT2A (0.66) MAPTGAACA1CA2CA9
SCHEMBL30435450 0.86 KMT2A (0.66) MAPTGAACA1CA2CA9
SCHEMBL30472476 0.85 PARP10 (0.61) MAPTGAASRD5A2PARP10POLB
SCHEMBL27188257 0.85 PARP10 (0.61) MAPTGAASRD5A2PARP10POLB
SCHEMBL10942759 0.84 SRD5A2 (0.50) MAPTGAACA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0368006-B1 Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties DOW CHEMICAL CO (US) 1995-04-05 EP disclosed
US-5151489-A Block copolymers for compression molding to form fibers, films and laminates THE DOW CHEMICAL COMPANY (US) 1992-09-29 US disclosed
US-5098985-A Block copolymers for films, fibers, laminates or compression moldings THE DOW CHEMICAL COMPANY (US) 1992-03-24 US disclosed
EP-0392008-A4 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES 1991-09-04 EP disclosed
EP-0392008-A1 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES THE DOW CHEMICAL COMPANY (US) 1990-10-17 EP disclosed
EP-0368006-A2 Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties THE DOW CHEMICAL COMPANY (US) 1990-05-16 EP disclosed
WO-1990003995-A1 COPOLYMERS CONTAINING POLYBENZOXAZOLE, POLYBENZOTHIAZOLE AND POLYBENZIMIDAZOLE MOIETIES THE DOW CHEMICAL COMPANY (US) 1990-04-19 WO disclosed