SCHEMBL5685223

SCHEMBL5685223

COc1ccc(C(=O)c2ccccc2N)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.66
MAPT P10636 3/20 0.65
GAA P10253 1/20 0.65
RAB9A P51151 3/20 0.59
KDM4E B2RXH2 1/20 0.59
NPC1 O15118 2/20 0.58
HDAC3 O15379 1/20 0.56
HDAC4 P56524 1/20 0.56
HDAC1 Q13547 1/20 0.56
HDAC7 Q8WUI4 1/20 0.56
HDAC2 Q92769 1/20 0.56
HDAC10 Q969S8 1/20 0.56
HDAC11 Q96DB2 1/20 0.56
HDAC8 Q9BY41 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
HDAC9 Q9UKV0 1/20 0.56
HDAC5 Q9UQL6 1/20 0.56
NPSR1 Q6W5P4 3/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
ALDH1A1 P00352 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30435450 1.00 KMT2A (0.66) KMT2AMAPTGAARAB9AKDM4E
SCHEMBL3195451 0.87 KMT2A (0.58) KMT2AMAPTGAARAB9AKDM4E
SCHEMBL8081475 0.86 MAPT (0.65) KMT2AMAPTGAARAB9ANPC1
SCHEMBL9252016 0.86 MAPT (0.69) KMT2AMAPTGAAALDH1A1CFTR
SCHEMBL9244900 0.86 MAPT (0.69) KMT2AMAPTGAAALDH1A1CFTR
Hydrochloric Acid SCHEMBL5226809 0.85 KMT2A (0.56) KMT2AMAPTGAARAB9AKDM4E
SCHEMBL8374908 0.85 MAPT (0.87) MAPTGAANPC1ALDH1A1TP53
SCHEMBL4260834 0.83 MAPT (0.56) KMT2AMAPTGAARAB9AKDM4E
SCHEMBL9248330 0.83 GAA (0.70) MAPTGAASMN1; SMN2CA1CA2
SCHEMBL8983004 0.83 NPC1 (0.68) KMT2AMAPTGAARAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250367649-A1 PHOTOCATALYSTS, PREPARATION AND USE THEREOF THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2025-12-04 US disclosed
EP-4461783-A1 ELECTROCHROMIC COMPOUNDS, COMPOSITIONS AND OPTICAL ARTICLES CONTAINING THEM Essilor International (FR) 2024-11-13 EP disclosed
WO-2023077218-A1 PHOTOCATALYSTS, PREPARATION AND USE THEREOF THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) 2023-05-11 WO disclosed
WO-2023077218-A1 PHOTOCATALYSTS, PREPARATION AND USE THEREOF THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) 2023-05-11 WO disclosed
EP-3419961-B1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF ALCON INC (CH) 2020-09-02 EP disclosed
US-10268053-B2 UV/visible-absorbing vinylic monomers and uses thereof NOVARTIS AG (CH) 2019-04-23 US disclosed
EP-3419961-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF Novartis AG (CH) 2019-01-02 EP disclosed
WO-2017145022-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF NOVARTIS AG (CH) 2017-08-31 WO disclosed
US-20170242274-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF ALCON INC. (CH) 2017-08-24 US disclosed
EP-2897945-B1 BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2016-12-21 EP disclosed
EP-0119441-A2 Reactive dyes with substituted 4-fluoropyridaz-6-one groups BASF Aktiengesellschaft (DE) 1984-09-26 EP disclosed
US-4473498-A Water-soluble, fiber-reactive organic dyestuffs containing a β-chloro-ethylsulfonyl-methyl-benzoic acid amide group HOECHST AKTIENGESELLSCHAFT (DE) 1984-09-25 US disclosed
EP-0109624-A2 Process for producing shaped articles made from polyurethane-polyurea which may be cellular BASF Aktiengesellschaft (DE) 1984-05-30 EP disclosed
US-4447361-A ANTIDEPRESSANT A. H. ROBINS COMPANY, INC. (US) 1984-05-08 US disclosed
EP-0012969-B1 WATER-SOLUBLE FIBRE-REACTIVE COMPOUNDS AND THEIR USE IN FIBRE FINISHING,ESPECIALLY AS DYESTUFFS,AND DIHALOGENO-PYRIDAZONYL-CARBOXYLIC AND SULFONIC ACID HALIDES AND THEIR USE AS FIBRE-REACTIVE ANCHORS,AS WELL AS PROCESS FOR THE PREPARATION OF THESE COMPOUND HOECHST AKTIENGESELLSCHAFT (DE) 1983-06-08 EP disclosed
EP-0076017-A2 Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor A.H. ROBINS COMPANY, INCORPORATED (US) 1983-04-06 EP disclosed
EP-0045488-A2 Water-soluble fibre-reactive compounds and their use in finishing textiles, as well as the beta-chloroethyl-sulfonyl-methyl-benzoic-acid halogenides, and their use as a fibre-reactive anchor HOECHST AKTIENGESELLSCHAFT (DE) 1982-02-10 EP disclosed
US-4313872-A MONDAZO AND DISAZO DYES CASSELLA AKTIENGESELLSCHAFT (DE) 1982-02-02 US disclosed
EP-0012969-A2 Water-soluble fibre-reactive compounds and their use in fibre finishing,especially as dyestuffs,and dihalogeno-pyridazonyl-carboxylic and sulfonic acid halides and their use as fibre-reactive anchors,as well as process for the preparation of these compound HOECHST AKTIENGESELLSCHAFT (DE) 1980-07-09 EP disclosed
US-4118384-A DIAZOTIZATION BAYER AKTIENGESELLSCHAFT (DE) 1978-10-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10268053-B2 UV/visible-absorbing vinylic monomers and uses thereof VCL, UACA, XRCC6 KMT2A 2430/4885MAPT 132/4885GAA 2532/4885
US-20250367649-A1 PHOTOCATALYSTS, PREPARATION AND USE THEREOF PPOX, AOX1, CYP3A7 KMT2A 1036/4885MAPT 3707/4885GAA 1307/4885
US-20170242274-A1 UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF VCL, UACA, XRCC6 KMT2A 2430/4885MAPT 132/4885GAA 2532/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.