Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17481205 | 0.73 | PDE10A (0.36) | LMNAHTTCOMT | |
| SCHEMBL21610924 | 0.70 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL21610914 | 0.70 | MEN1 (0.33) | NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL21610915 | 0.68 | MEN1 (0.35) | NPC1ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL21610917 | 0.64 | — | — | |
| SCHEMBL327473 | 0.62 | CNR1 (0.37) | LMNAHTTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL13816403 | 0.60 | — | — | |
| SCHEMBL77218 | 0.59 | — | — | |
| SCHEMBL12537263 | 0.59 | COMT (0.52) | CDK4CCNE1CDK2LMNAHTT | |
| SCHEMBL12607741 | 0.58 | GAA (0.36) | HTTALDH1A1MAPTPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |