SCHEMBL92524

SCHEMBL92524

CN1C(=O)c2ccc(-c3ccccc3)cc2C1=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 4/20 0.57
MEN1 O00255 3/20 0.53
MAPT P10636 3/20 0.53
KMT2A Q03164 3/20 0.53
L3MBTL1 Q9Y468 3/20 0.53
APAF1 O14727 1/20 0.53
NPC1 O15118 1/20 0.53
LMNA P02545 1/20 0.53
THRB P10828 1/20 0.53
XBP1 P17861 1/20 0.53
PTBP1 P26599 1/20 0.53
HTT P42858 1/20 0.53
RAB9A P51151 1/20 0.53
GALK1 P51570 1/20 0.53
BLM P54132 1/20 0.53
SMAD3 P84022 1/20 0.53
ATM Q13315 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
CASP3 P42574 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10053401 0.90 ALDH1A1 (0.59) APPMEN1MAPTKMT2AL3MBTL1
SCHEMBL14454547 0.86 MEN1 (0.47) APPMEN1MAPTKMT2AL3MBTL1
SCHEMBL10635915 0.83 ALDH1A1 (0.49) APPMEN1MAPTKMT2AL3MBTL1
SCHEMBL13574906 0.81 KDM4E (0.58) MEN1MAPTKMT2AL3MBTL1APAF1
SCHEMBL28816202 0.81 KMT2A (0.53) MEN1MAPTKMT2AL3MBTL1APAF1
SCHEMBL7686013 0.81 KMT2A (0.53) MEN1MAPTKMT2AL3MBTL1APAF1
SCHEMBL10246381 0.80 KDM4E (0.58) MEN1MAPTKMT2AL3MBTL1APAF1
SCHEMBL13016992 0.79 ALDH1A1 (0.49) APPMEN1MAPTKMT2AL3MBTL1
SCHEMBL19047110 0.79 ALDH1A1 (0.49) APPMEN1MAPTKMT2AL3MBTL1
SCHEMBL14560527 0.79 KDM4E (0.60) MEN1MAPTKMT2AL3MBTL1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8369204-B2 Method for high density data storage and imaging INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2013-02-05 US disclosed
US-20120155242-A1 METHOD FOR HIGH DENSITY DATA STORAGE AND IMAGING INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2012-06-21 US disclosed
US-8129496-B2 Method for high density data storage and imaging INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2012-03-06 US disclosed
US-20120028955-A1 BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME VANDERBILT UNIVERSITY 2012-02-02 US disclosed
US-20120028956-A1 BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME VANDERBILT UNIVERSITY 2012-02-02 US disclosed
US-8102753-B2 Method for forming deformed regions in a resin layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2012-01-24 US disclosed
US-8034806-B2 Bicyclic mGluR5 positive allosteric modulators and methods of making and using same VANDERBILT UNIVERSITY (US) 2011-10-11 US disclosed
US-20090270362-A1 BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME VANDERBILT UNIVERSITY 2009-10-29 US disclosed
EP-1994078-B1 METHOD FOR HIGH DENSITY DATA STORAGE AND IMAGING IBM (US) 2009-07-01 EP disclosed
WO-2008151184-A1 BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME VANDERBILT UNIVERSITY (US) 2008-12-11 WO disclosed
US-20080219135-A1 METHOD FOR HIGH DENSITY DATA STORAGE AND IMAGING GLOBALFOUNDRIES U.S. INC. 2008-09-11 US disclosed
US-20080175135-A1 DATA STORAGE MEDIUM AND METHOD FOR HIGH DENSITY DATA STORAGE DUERIG URS T 2008-07-24 US disclosed
US-20080076903-A1 DATA STORAGE MEDIUM AND METHOD FOR HIGH DENSITY DATA STORAGE INTERNATIONAL BUSINESS MACHINES CORPORATION 2008-03-27 US disclosed
WO-2007096359-A2 METHOD FOR HIGH DENSITY DATA STORAGE AND IMAGING INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2007-08-30 WO disclosed
US-20070195682-A1 METHOD FOR HIGH DENSITY DATA STORAGE AND IMAGING GLOBALFOUNDRIES INC. (KY) 2007-08-23 US disclosed
US-20070196645-A1 Method for high density data storage and imaging INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2007-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120028955-A1 BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME GRM5, GRIK5, GRM1 APP 1978/4885MEN1 4490/4885MAPT 743/4885
US-20120028956-A1 BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME GRM5, GRIK5, GRM1 APP 1978/4885MEN1 4490/4885MAPT 743/4885
US-20090270362-A1 BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME GRM5, GRIK5, GRM1 APP 1978/4885MEN1 4490/4885MAPT 743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.