Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.56 |
| ▸ | HTR2B | P41595 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HRH2 | P25021 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848087 | 0.88 | SMN1; SMN2 (0.77) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2A | |
| SCHEMBL9256664 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2A | |
| SCHEMBL4063564 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19HTT | |
| SCHEMBL14335634 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2A | |
| SCHEMBL5229150 | 0.80 | TMEM97 (0.56) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2A | |
| SCHEMBL9256804 | 0.80 | HTR2A (0.81) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL19950156 | 0.79 | MEN1 (0.60) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2A | |
| SCHEMBL5237843 | 0.79 | KMT2A (0.54) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL205216 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9ACYP2C19HTT | |
| SCHEMBL31449815 | 0.78 | SMN1; SMN2 (0.87) | SMN1; SMN2NPC1RAB9ACYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441967-A | Treating cerebral edema; anticholinesterase or brain function-improving agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| US-5294625-A | 1-benzyl,4-((4-dialkylaminophenyl)carbonyl)piperidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0378207-B1 | CYCLIC AMINE COMPOUNDS AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-5177087-A | Cerebral edema, cholinesterase inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |