Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848087 | 0.91 | SMN1; SMN2 (0.77) | SMN1; SMN2NPC1RAB9ACYP2C19HSD11B1 | |
| SCHEMBL4063564 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19HTT | |
| SCHEMBL14335634 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19HSD11B1 | |
| SCHEMBL9253050 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9ACYP2C19CYP2D6 | |
| SCHEMBL1653094 | 0.83 | HTT (0.69) | SMN1; SMN2NPC1RAB9ACYP2C19CYP2D6 | |
| SCHEMBL10600330 | 0.83 | HSD11B1 (0.65) | SMN1; SMN2CYP2C19HSD11B1KDM4ECYP2C9 | |
| SCHEMBL205216 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4 | |
| SCHEMBL7492647 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4 | |
| SCHEMBL6208288 | 0.81 | HSD11B1 (0.67) | SMN1; SMN2CYP2C19HSD11B1CYP1A2CYP3A4 | |
| SCHEMBL5369606 | 0.81 | TPSAB1 (0.69) | SMN1; SMN2NPC1RAB9ACYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441967-A | Treating cerebral edema; anticholinesterase or brain function-improving agent | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| US-5294625-A | 1-benzyl,4-((4-dialkylaminophenyl)carbonyl)piperidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-15 | — | — | US | disclosed |
| EP-0378207-B1 | CYCLIC AMINE COMPOUNDS AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-5177087-A | Cerebral edema, cholinesterase inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |