Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626216 | 0.79 | IDO1 (0.51) | CYP2D6SIGMAR1IDO1 | |
| SCHEMBL10904064 | 0.76 | IDO1 (0.53) | CYP2D6SIGMAR1IDO1 | |
| SCHEMBL5809770 | 0.74 | HTR2C (0.50) | CYP2D6PRCPIDO1 | |
| SCHEMBL12228557 | 0.71 | SIGMAR1 (0.40) | SIGMAR1IDO1 | |
| SCHEMBL10571574 | 0.71 | PRCP (0.43) | CYP2D6SIGMAR1PRCP | |
| SCHEMBL11007168 | 0.70 | CYP3A4 (0.42) | CYP2D6 | |
| SCHEMBL3886571 | 0.70 | SIGMAR1 (0.46) | CYP2D6SIGMAR1PRCP | |
| SCHEMBL30728437 | 0.68 | GPR84 (0.57) | SIGMAR1IDO1 | |
| SCHEMBL19529546 | 0.66 | GPR84 (0.59) | IDO1 | |
| SCHEMBL20433856 | 0.66 | GPR84 (0.59) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5301859-A | — | — | None | — | — | JP | disclosed |
| EP-0534344-B1 | Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines, a process for their preparation and their use as modulators of neurotransmitter function | HOECHST ROUSSEL PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| JP-H05301859-A | SUBSTITUTED 3-AMINO-2,3,4,5-TETRAHYDRO-1-ARYLOXY-3-BENZAZEPINES | HOECHST ROUSSEL PHARMACEUT INC | 1993-11-16 | — | — | JP | disclosed |
| US-5202319-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0534344-A1 | Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines, a process for their preparation and their use as modulators of neurotransmitter function | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-03-31 | — | — | EP | disclosed |