Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | DPYD | Q12882 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1737697 | 0.79 | CHEK1 (0.56) | JAK3MAP3K7TAB1CHEK1CHUK | |
| SCHEMBL7885565 | 0.72 | MAPK1 (0.39) | JAK3MAP3K7TAB1CHEK1CHUK | |
| SCHEMBL7887899 | 0.72 | CHEK1 (0.61) | JAK3MAP3K7TAB1CHEK1CHUK | |
| SCHEMBL15618411 | 0.68 | IRAK4 (0.47) | MAP3K7TAB1CHEK1LRRK2IRAK4 | |
| SCHEMBL30975034 | 0.68 | IRAK4 (0.47) | JAK3MAP3K7TAB1CHEK1LRRK2 | |
| SCHEMBL1806375 | 0.65 | MAP3K7 (0.41) | JAK3MAP3K7TAB1CHEK1NOTUM | |
| SCHEMBL30849541 | 0.63 | LRRK2 (0.33) | LRRK2DPYD | |
| SCHEMBL14649086 | 0.61 | MAP3K7 (0.56) | MAP3K7TAB1CHUKHSP90AB1LRRK2 | |
| SCHEMBL12590787 | 0.60 | CHUK (0.48) | JAK3MAP3K7TAB1CHUKHSP90AB1 | |
| SCHEMBL31612016 | 0.59 | CDC7 (0.50) | JAK3MAP3K7TAB1CHEK1CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426187-A | Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |