Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | MTAP | Q13126 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16922228 | 0.73 | MAP3K7 (0.67) | MAP3K7TAB1 | |
| SCHEMBL16922240 | 0.71 | MAP3K7 (0.57) | MAP3K7TAB1JAK3CHEK1TRPA1 | |
| SCHEMBL16922247 | 0.69 | CDK1 (0.46) | MAP3K7TAB1JAK3CHEK1TRPA1 | |
| SCHEMBL7885565 | 0.68 | MAPK1 (0.39) | MAP3K7TAB1JAK3CHEK1NOTUM | |
| SCHEMBL7887899 | 0.68 | CHEK1 (0.61) | MAP3K7TAB1JAK3CHEK1NOTUM | |
| SCHEMBL1804027 | 0.68 | AKT1 (0.44) | CHEK1TRPA1 | |
| SCHEMBL1828363 | 0.67 | GABRA1 (0.31) | GABRA1GABRB2 | |
| SCHEMBL2059464 | 0.67 | CDC7 (0.35) | L3MBTL1GABRA1GABRB2 | |
| SCHEMBL9254230 | 0.65 | JAK3 (0.39) | MAP3K7TAB1JAK3CHEK1NOTUM | |
| SCHEMBL15618411 | 0.65 | IRAK4 (0.47) | MAP3K7TAB1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535251-B | Process for preparing 5-alkyl-7h-pyrrolo[2,3-d]pyrimidine-2-ols | LEXICON PHARMACEUTICALS INC | 2012-08-22 | — | — | CN | disclosed |
| EP-2084130-B1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2-OLS | LEXICON PHARMACEUTICALS INC (US) | 2012-06-27 | — | — | EP | disclosed |
| EP-2084130-B1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2-OLS | LEXICON PHARMACEUTICALS INC (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7951941-B2 | Process for preparing 5-alkyl-7H-pyrrolo[2,3-d] pyrimindine-2-ols | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951941-B2 | Process for preparing 5-alkyl-7H-pyrrolo[2,3-d] pyrimindine-2-ols | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| CN-101535251-A | Process for preparing 5-alkyl-7h-pyrrolo[2,3-d]pyrimidine-2-ols | LEXICON PHARMACEUTICALS INC (US) | 2009-09-16 | — | — | CN | disclosed |
| EP-2084130-A1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2-OLS | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-2084130-A1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2-OLS | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008051887-A1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2-OLS | LEXICON PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008051887-A1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2-OLS | LEXICON PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| US-20080097098-A1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-d] PYRIMINDINE-2-OLS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2008-04-24 | — | — | US | disclosed |
| US-20080097098-A1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-d] PYRIMINDINE-2-OLS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080097098-A1 | PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-d] PYRIMINDINE-2-OLS | THPO, DHPS, DPYD | MAP3K7 974/4885TAB1 4734/4885JAK3 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.