Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 6/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248672 | 0.90 | PTGER4 (0.40) | PTGER4PLK1NAMPTALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL9254196 | 0.90 | JAK2 (0.45) | PTGER4PLK1JAK2JAK1TYK2 | |
| SCHEMBL9245485 | 0.88 | PTGER4 (0.48) | PTGER4PLK1JAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL9255414 | 0.88 | JAK2 (0.44) | PTGER4PLK1JAK2JAK1TYK2 | |
| SCHEMBL9248676 | 0.87 | ALDH1A1 (0.39) | PTGER4PLK1NAMPTALDH1A1CYP2D6 | |
| SCHEMBL9252687 | 0.86 | JAK2 (0.45) | PTGER4PLK1JAK2JAK1TYK2 | |
| SCHEMBL9248606 | 0.86 | EHMT2 (0.49) | PTGER4JAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL9251668 | 0.85 | SIRT2 (0.46) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9252106 | 0.85 | JAK2 (0.44) | PTGER4PLK1JAK2JAK1TYK2 | |
| SCHEMBL9251618 | 0.85 | JAK2 (0.51) | PTGER4PLK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |