Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9250249 | 0.89 | ACE (0.58) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9259213 | 0.86 | ACE (0.37) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9252296 | 0.82 | ACE (0.59) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9259207 | 0.81 | CYP1A2 (0.42) | CYP3A4 | |
| SCHEMBL9739401 | 0.77 | ACE (0.49) | ACE | |
| SCHEMBL9250708 | 0.76 | TSHR (0.47) | KMT2A | |
| SCHEMBL10700347 | 0.76 | ACE (0.55) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL11021440 | 0.76 | ACE (0.55) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL9254110 | 0.75 | L3MBTL1 (0.31) | — | |
| SCHEMBL9254116 | 0.75 | L3MBTL1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401766-A | Hypotensive agents with vasodilation | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5162362-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | disclosed |
| US-5158959-A | Treatment of hypertension | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-27 | — | — | US | disclosed |