Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9382181 | 1.00 | ALDH1A1 (0.50) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL9259375 | 0.90 | MAPT (0.46) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL9259373 | 0.90 | MAPT (0.46) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL9270457 | 0.89 | KMT2A (0.46) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL9270452 | 0.89 | KMT2A (0.46) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL9261891 | 0.88 | KMT2A (0.45) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL9261887 | 0.88 | KMT2A (0.45) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL9258314 | 0.87 | KMT2A (0.44) | ALDH1A1MAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL9258566 | 0.87 | KMT2A (0.44) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL9262397 | 0.87 | KMT2A (0.44) | ALDH1A1MAPTKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476944-A | Inhibitors or stimulators of superoxide generation; may also inhibit cyclooxygenase and/or 5-lipoxygenase; useful in therapeutic or prophylactic treatment of disease conditions | G. D. SEARLE & CO. (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0613463-A1 | DERIVATIVES OF CYCLIC PHENOLIC THIOETHERS AS INHIBITORS OR STIMULATORS OF SUPEROXIDE GENERATION | G.D. SEARLE & CO. (US) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010087-A1 | DERIVATIVES OF CYCLIC PHENOLIC THIOETHERS AS INHIBITORS OR STIMULATORS OF SUPEROXIDE GENERATION | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |