Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259373 | 1.00 | MAPT (0.46) | MAPTALDH1A1NPC1RAB9ASIRT2 | |
| SCHEMBL9254864 | 0.90 | ALDH1A1 (0.50) | MAPTALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL9382181 | 0.90 | ALDH1A1 (0.50) | MAPTALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL9264228 | 0.85 | KMT2A (0.43) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9600856 | 0.85 | KMT2A (0.43) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9263781 | 0.85 | KMT2A (0.43) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9263786 | 0.85 | KMT2A (0.43) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9265614 | 0.85 | KMT2A (0.44) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9265611 | 0.85 | KMT2A (0.44) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9381098 | 0.84 | KMT2A (0.42) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476944-A | Inhibitors or stimulators of superoxide generation; may also inhibit cyclooxygenase and/or 5-lipoxygenase; useful in therapeutic or prophylactic treatment of disease conditions | G. D. SEARLE & CO. (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1993010087-A1 | DERIVATIVES OF CYCLIC PHENOLIC THIOETHERS AS INHIBITORS OR STIMULATORS OF SUPEROXIDE GENERATION | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |