Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9177428 | 0.90 | TP53 (0.46) | HIF1ATP53KDM4ETSHRNOTUM | |
| SCHEMBL9177267 | 0.86 | NOTUM (0.41) | HIF1ATP53KDM4ETSHRNOTUM | |
| SCHEMBL9281952 | 0.84 | HIF1A (0.35) | HIF1ATP53KDM4ETSHRNOTUM | |
| SCHEMBL9254901 | 0.82 | HIF1A (0.61) | HIF1ATP53KDM4ETSHRMAPT | |
| SCHEMBL9177444 | 0.81 | NOTUM (0.40) | HIF1ATSHRNOTUMALDH1A1GAA | |
| SCHEMBL22639677 | 0.78 | KDM4E (0.50) | TP53KDM4ETSHRNOTUMMAPT | |
| SCHEMBL9176272 | 0.76 | NOTUM (0.39) | TSHRNOTUMMAPTIDO1 | |
| SCHEMBL10379466 | 0.76 | MAP3K8 (0.50) | TP53KDM4ETSHRNOTUMMAPT | |
| SCHEMBL9176240 | 0.76 | NOTUM (0.39) | TSHRNOTUMMAPTIDO1 | |
| SCHEMBL16099136 | 0.76 | NOTUM (0.42) | HIF1AKDM4ETSHRNOTUMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426467-B1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RES FOUND (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5120740-A | PRODRUGS OF 6-MERCAPTOPURINE AND 6-THIOGUANINE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0426467-A1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-05-08 | — | — | EP | disclosed |