Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 4/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9177431 | 0.89 | TP53 (0.67) | HIF1ATSHRTP53KDM4EMAPT | |
| SCHEMBL29098331 | 0.86 | HIF1A (0.65) | HIF1ATSHRTP53KDM4EMAPT | |
| SCHEMBL9173815 | 0.86 | HIF1A (0.65) | HIF1ATSHRTP53KDM4EMAPT | |
| SCHEMBL9281954 | 0.83 | HIF1A (0.56) | HIF1ATSHRTP53KDM4EMAPT | |
| SCHEMBL9254896 | 0.82 | HIF1A (0.39) | HIF1ATSHRTP53KDM4EMAPT | |
| SCHEMBL9177455 | 0.82 | HIF1A (0.57) | HIF1ATSHRTP53KDM4EMAPT | |
| SCHEMBL8696237 | 0.79 | TSHR (0.72) | HIF1ATSHRTP53KDM4EMAPT | |
| SCHEMBL9176257 | 0.76 | TSHR (0.56) | HIF1ATSHRALDH1A1CDC7DBF4 | |
| SCHEMBL30999504 | 0.76 | TSHR (0.56) | HIF1ATSHRALDH1A1CDC7DBF4 | |
| SCHEMBL9176248 | 0.76 | TSHR (0.56) | HIF1ATSHRALDH1A1CDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426467-B1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RES FOUND (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5120740-A | PRODRUGS OF 6-MERCAPTOPURINE AND 6-THIOGUANINE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0426467-A1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-05-08 | — | — | EP | disclosed |