Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.82 |
| ▸ | SRC | P12931 | 1/20 | 0.82 |
| ▸ | GABRP | O00591 | 7/20 | 0.77 |
| ▸ | GABRD | O14764 | 7/20 | 0.77 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.77 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.77 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.77 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.77 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.77 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.77 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.77 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.77 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.77 |
| ▸ | GABRE | P78334 | 7/20 | 0.77 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.77 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.77 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.77 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.77 |
| ▸ | TNKS | O95271 | 2/20 | 0.66 |
| ▸ | PARP1 | P09874 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786642 | 0.92 | GABRP (0.70) | EGFRSRCGABRPGABRDGABRA1 | |
| SCHEMBL17786600 | 0.85 | EGFR (0.82) | EGFRSRCGABRPGABRDGABRA1 | |
| 6-Aminoflavone SCHEMBL31550004 | 0.84 | EGFR (0.82) | EGFRSRCGABRPGABRDGABRA1 | |
| 6-Aminoflavone SCHEMBL926716 | 0.84 | EGFR (0.82) | EGFRSRCGABRPGABRDGABRA1 | |
| SCHEMBL17786571 | 0.84 | EGFR (0.76) | EGFRSRCGABRPGABRDGABRA1 | |
| SCHEMBL17786560 | 0.84 | GABRP (0.79) | EGFRSRCGABRPGABRDGABRA1 | |
| SCHEMBL925773 | 0.81 | MAPT (0.79) | EGFRSRCGABRPGABRDGABRA1 | |
| SCHEMBL2426329 | 0.80 | TNKS (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17786474 | 0.79 | EGFR (0.72) | EGFRSRCGABRPGABRDGABRA1 | |
| SCHEMBL17786489 | 0.79 | EGFR (0.72) | EGFRSRCGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083490-A1 | COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES | REMYND NV (BE) | 2016-06-02 | — | — | WO | disclosed |
| US-8372866-B2 | 2-aryl and 2-heteroaryl 4H-1-benzopyran-4-one-6-amidino derivatives, new pharmacological agents for the treatment of arthritis, cancer and related pain | ROTTAPHARM S.P.A. (IT) | 2013-02-12 | — | — | US | disclosed |
| US-8372866-B2 | 2-aryl and 2-heteroaryl 4H-1-benzopyran-4-one-6-amidino derivatives, new pharmacological agents for the treatment of arthritis, cancer and related pain | ROTTAPHARM S.P.A. (IT) | 2013-02-12 | — | — | US | disclosed |
| US-8372866-B2 | 2-aryl and 2-heteroaryl 4H-1-benzopyran-4-one-6-amidino derivatives, new pharmacological agents for the treatment of arthritis, cancer and related pain | ROTTAPHARM S.P.A. (IT) | 2013-02-12 | — | — | US | disclosed |
| EP-2268628-B1 | 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | ROTTAPHARM SPA (IT) | 2012-05-16 | — | — | EP | disclosed |
| US-20110003861-A1 | 2-ARYL AND 2-HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES, NEW PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | ROTTAPHARM S.P.A. (IT) | 2011-01-06 | — | — | US | disclosed |
| US-20110003861-A1 | 2-ARYL AND 2-HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES, NEW PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | ROTTAPHARM S.P.A. (IT) | 2011-01-06 | — | — | US | disclosed |
| US-20110003861-A1 | 2-ARYL AND 2-HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES, NEW PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | ROTTAPHARM S.P.A. (IT) | 2011-01-06 | — | — | US | disclosed |
| EP-2268628-A1 | 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | Rottapharm S.p.A. (IT) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009109230-A1 | 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | ROTTAPHARM S.P.A. (IT) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009109230-A1 | 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | ROTTAPHARM S.P.A. (IT) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003861-A1 | 2-ARYL AND 2-HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES, NEW PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN | NAT1, AADAC, OPRL1 | EGFR 1202/4885SRC 896/4885GABRP 1278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.