Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9229297 | 0.82 | ALOX5 (0.45) | ALOX5 | |
| SCHEMBL1599480 | 0.76 | ALOX5 (0.54) | ALOX5 | |
| SCHEMBL1598547 | 0.75 | ALOX5 (0.51) | ALOX5PTGS1PTGS2 | |
| SCHEMBL8698139 | 0.75 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL12199577 | 0.73 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL31543489 | 0.73 | ALOX5 (0.39) | ALOX5 | |
| SCHEMBL9226945 | 0.72 | ALOX5 (0.38) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9220205 | 0.71 | SLC6A2 (0.30) | — | |
| SCHEMBL7481034 | 0.68 | ALOX5 (0.53) | ALOX5PTGS1PTGS2 | |
| SCHEMBL8630364 | 0.68 | ALOX5 (0.42) | ALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |